Optimization of cross linked tragacanth and comparison of drug release rate profile with synthetic superdisintegrants on metoclopramide orodispersible tablets

Fast dissolving dosage forms can be disintegrated, dissolved, or suspended by saliva in the mouth. This fast dissolving tablet disintegrates instantaneously when placed on tongue and releases the drug dissolves or disperses in the saliva. Fast dissolving tablets are useful in patients, like pediatric, geriatric, bedridden, or mentally disabled, who may face difficulty in swallowing conventional tablets or capsules leading to ineffective therapy, with persistent nausea, sudden episodes of allergic attacks, or coughing for those who have an active life style. Present investigation is to optimize the cross linked tragacanth as natural super disintegrants and comparison of drug release profile with SSG, Crospovidone by direct compression using metoclopromide hydrochloride. From the dissolution profiles, Optimized formulation found to be C3, 1:0.8 in ratio of Dry tragacanth powder and epichlorhydrin. Different drug formulations are prepared by direct compression. From the drug release profiles it is concluded that formulation with 4% of optimized CLT by direct compression have highest drug release of 95.39% at the end of 15mins when compare to other formulations and natural superdisintegrants have more efficiency than synthetic superdisintegrants. Key-Words: Metoclopromide Hydrochloride, Cross Linked Trgacanth, SSG, Crospovidone Introduction Patient compliance, high-precision dosing, and manufacturing efficiency make tablets the solid dosage form of choice. Many conventional oral drug products, such as tablets and capsules, are formulated to release the active drug immediately after oral administration to obtained rapid and complete systemic drug absorption. Such immediate release products results in relatively rapid drug absorption and onset of accompanying pharmacodynamic effects. Tablets are the most widely used dosage form because of its convenience in terms of selfadministration, compactness and ease in manufacturing. Patients, particularly pediatric and geriatric patients, have difficulty in swallowing these solid dosageforms. These patients are unwilling to take these solid preparations due to a fear of choking. In some cases such as motion sickness, sudden episodes of allergic attacks or coughing and unavailability of water, swallowing conventional tablets may be difficult. * Corresponding Author Email: [email protected] Inorder to assist these patients, several mouth dissolving drug delivery systems has been developed. When ODT (Oro dispersible Tablets) put on tongue, this tablet disintegrates instantaneously, releasing the drug, which dissolves or disperses in the saliva. Some drugs are absorbed from the mouth, pharynx and oesophagus as the saliva passes down into the stomach. In such cases, bioavailability of drug is significantly greater than those observed from conventional tablet dosage form. Metoclopramide hydrochloride a derivative of para amino benzoic acid, is a commonly prescribed drug used for the management of gastrointestinal disorders such as gastric stasis, gastroesophageal reflux and for the prevention of cancer chemotherapyinduced emesis. In general, emesis is preceded with nausea and in such condition it is difficult to administer drug with a glass of water; hence it is beneficial to administer such drugs as ODTs. The main objective of this research is to optimize the concentration of tragacanth powder and epichlorhydrin in preparation of cross linked tragacanth which is natural superdisintegrant and comparison of drug release profile with synthetic supersisintegrants like SSG, Crosspovidone by direct compression method. Research Article [Divya et al., 4(3): March., 2013] CODEN (USA): IJPLCP ISSN: 0976-7126 Int. J. of Pharm. & Life Sci. (IJPLS), Vol. 4, Issue 3: March: 2013, 2500-2505 2501 Material and Methods Metoclopramide Hydrochloride was obtained as a gift sample from Wallace Pharmaceuticals pvt. Ltd. Goa, Sodium starch glycolate was obtained from Micro labs, Bangalore; Crospovidone was obtained from Yarrow chemicals, Mumbai. All other chemicals used in the study were of analytical grade. Methods Optimization of cross linked tragacanth A chemical method was used for the preparation of cross linked tragacanth. Dry tragacanth powder and epichlorhydrin in different ratios like 1:0.2, 1:0.5 and 1:0.8 were allowed to react at temperatures ranging from 37c to 105c. The reaction time was varied in between 45-100min. The results also revealed that at 37c, cross linking of tragacanth was not achieved at all the ratios tried in the present study. As the boiling point epichlorhydrin is 116c, the cross linking reaction was carried out in the range of 60c to105c. The temperature of cross linking reaction exhibited significant effect on the reaction rate. Based on the results of intrinsic properties, optimum conditions for cross linking of tragacanth were found to be a) 1 : 0.8 ratio of tragacanth : epichlorhydrin. b) Temperature of reaction of reaction as 105c. c) Time of reaction as 95min.